鲁白是世界上有影响的闻名神经迷信家,结业于华东师范年夜学,在年夜脑发育以及精力康健畛域作出了一系列重年夜迷信发明,是《常识份子》的主编。
神经生物学家鲁白传授
次要履历:
鲁白博士现为新成立的清华年夜学药学院毕生传授。他曾经在学术界以及产业界担当一系列的向导职务,如清华年夜学医学院常务副院长(2013-2016),葛兰素史克研发部副总裁卖力神经退行性疾病药物研发(2009-2013)。在此以前,鲁白曾经在美国国立康健研究院(NIH)事情14年,历任突触发育试验室主任,神经发育研究室主任, 基因、认知与精力研究部(GCAP)副部长。他在美国康乃尔(Cornell)年夜学医学院得到博士学位,并在洛克菲勒(Rockefeller)年夜学做博士后,师从诺贝尔奖患上主Paul Greengard。
次要学术成绩:
鲁白博士的研究乐趣涵盖神经迷信与神经,精力疾病、模式植物、发育生物学、遗传学与人类基因组研究等方面,颁发迷信论文100多篇。持久从事神经发育与突触可塑性的研究,有多项首要发明。1996年发明神谋划养因子(BDNF)对学习影象机制的促成作用,与国际上几位学者一块儿,创始了神谋划养因子调控突触以及神经可塑性的新畛域。他与Weinberge传授一块儿发明人的BDNF基因上的一个单核甘酸变异(SNP)能影响BDNF在脑中的开释,从而扭转学习影象功用。该事情被Science杂志列为2003年世界十年夜科技入铺中的第二位。他还发明了BDNF前体proBDNF剪切后发生成熟mBDNF,促成突触可塑性以及永劫影象机制,而proBDNF按捺突触可塑性。基于mBDNF以及proBDNF之间的对峙瓜葛,提出了“神谋划养因子作用中的阴阳机制” 假说。鲁白试验室持久从事认知的神经环路研究,应用模式植物,电心理,成像和光遗传学手腕,研究前额叶皮层脑认知功用。比年来的研究乐趣扩大到转化医学,用电心理学、举动学及成像技能来探究认知以及脑的其余高档功用,及神经,精力疾病的病发机理。并从事神谋划养因子及神经退行性疾病的新药研发;2013年提出“基于BDNF的突触修复”,医治神经退行性疾病的新战略,引发普遍存眷。
药物研发事情:
曾经担当跨国药企GSK的研发副总裁,卖力: 1) 神经体系药物研发的整体生物学策略, 2) 神经退行性疾病药物研发管线以及3个研发部的治理, 3) 药物新靶点发明研究, 4) 初期临床以及试验医学研究, 5) 对外互助以及商物成长。他向导的团队曾经开收回检测人类年夜脑突触功用停滞的生物标识表记标帜物,用遗传学以及影像学作病人选择的临床实验新方式,并研制出可以或许激活神谋划养因子通路的抗体候选药。
学术声誉以及勾当:
担当多个国际基金会的评审专家,国际神经迷信杂志的編委,多家国际学术集团,研究所的迷信参谋,理事,董事会成员。屡次掌管首要国际性的学术集会。自1994年来应邀在国际学术集会,世界各地闻名年夜学以及研究所作学术陈述250余次,年夜会特邀以及主题陈述14次。获殷之浩荡陆精采青年迷信家奖,中国国度天然迷信基金-精采青年B类, NIH院长讲座奖, APAO精采成绩奖, Mathilde Solowey奖,及Ray Wu奖,等等。2014被汤森路透(Thomson Reuters)评为“世界最有影响力的神经迷信家”,是独一一位在中国事情的迷信家。近3年一连进选爱思唯尔(Elsevier)“中国高被引神经迷信畛域迷信家”。今朝还担当”北京市人脑高精尖中间”副主任兼首席迷信家,北京市“医药康健协同立异举措规划“专家委员会主任委员。
比年来还致力于迷信传布。他以及北京年夜学的饶毅传授,普林斯顿年夜学的谢宇传授配合创立了科技新媒体“常识份子”,今朝已经经成为中国最有影响力的科技自媒体之一。2017年起担当平易近间GASA年夜黉舍董,率领优异企业家出国粹习迷信前沿以及新兴科技。介入创立多家高科技企业。2018年被聘为北京市策略成长专家组组长,介入北京市“科创中间”的事情。2018年起还担当“北京智源”理事会理事;北京市海淀区迷信参谋;华东师年夜成长征询委员会委员;复旦年夜黉舍友会副会长,等等。2018秋季担当中央电视1台《机警过人》节目主佳宾。
其余与科技无关的社会勾当:
· 1995年与旅美迷信家饶毅以及梅林配合主建中科院上海份子神经生物学研究室,在此根本上,1998年与蒲慕明传授等一块儿建立中科院神经迷信研究所
· 1998年在北京掌管召开Gordon Conference,是首次在中国引入高端国际学术集会
· 1999任中国迷信院首批海外评审专家
· 2002任中国迷信院上海生物医药工业化独一的海外参谋
· 2003应邀任中国科技部的2位海外参谋之一,征询国度科技中持久计划
· 2003-2005创始并掌管国度天然迷信基金会海外专家评审会;该轨制持续至今
· 屡次就中国的迷信教诲,人材培育,生物产业等接受中美兩国闻名媒体专访,颁发评论
· 2008起协助筹建中国McGovern脑与认知研究所
· 2009开办GSK科技立异奖
· 2014年与饶毅,谢宇一块儿开办微信公家账号“赛师长教师”,后改成“常识份子”,现为海内次要科技传媒之一
· 2016年应邀成为长城会7位GASA年夜黉舍董之一(其余校董:李开复,杨培东,张宏江,张首晟,Tom Mitchel, 沈南鹏)
· 2018年被聘为北京市策略成长专家,海淀区迷信参谋
首要的原始论文 (共100多篇已经颁发)
1. S. Wang, H. Yao, Y. Xu, R. Hao, W. Zhang, H. Liu, Y. Huang, W. Guo,B. Lu(2020). Therapeutic potential of a TrkB agonist antibody for Alzheimer’s disease.Theranostics.In press.
2. H. You, P. C. Chu, W. Guo,B. Lu(2020) A subpopulation of Bdnf-e1-expressing glutamatergic neurons in the lateral hypothalamus critical for thermogenesis control.Molecular Metabolism.31:109-123.
3.W. Guo, Y. Chen, K. Pang, H. Li, S. Wang, H. Yao1, Y. Xu, H. Liu, V. Lopes-Rodrigues, W. Wu, B. Lu (2019). TrkB agonist antibodies with unique properties superior to BDNF.Neurobiology of Diseases. 132; xxx.Significant paper, developed a novel TrkB agonist antibodies with unique properties superior to BDNF.
4. F. Han, X. M. Guan, W. Guo,B. LuTherapeutic potential of a TrkB agonistic antibody for ischemic brain injury.Neurobiology of Diseases. 127:570-581. 2017.Significant paper, demonstrated that the novel TrkB antibodies could be used for the treatment of stroke.
5. K. Sakata K. Martinowich, N. H. Woo, D. V. Jimenez, R. Schlosser, Y. Ji., L. Shen,B. LuRole of activity-dependent BDNF expression in hippocampal-prefrontal cortical regulation of behavioral perseverance.Proc. Natl. Acad. Sci. USA.110:15103-15118. 2013.Significant paper, revealed that activity-dependent BDNF expression is critical for behavioral flexibility.
6. H. –S. Je, S. Portruli, F. Yang, H. –S. Je, , S. Portruli, Y. Ji, G. Nagappan, B. Hempstead, Y. Son, andB. LuRole of proBDNF to mature BDNF conversion in activity-dependent competition at developing neuromuscular synapses.Proc. Natl. Acad. Sci. USA.109, 15924-15929. 2012Significant paper, revealed a molecular mechanism underlying activity-dependent synaptic competition, a central issue in developmental neurobiology.
7. B. Fischer, J. Reis, K. Martinowich, H. M. Schambra, Y. Ji, L. Cohen,B. LuDC Stimulation-Enhanced Motor Learning Is Mediated by BDNF-dependent Long-term Synaptic Potentiation.Neuron66, 198-204. 2010.Significant paper, demonstrated a way to manipulate BDNF secretion in human brain in vivo.
8.Y. Ji, Y. Lu, L. Feng, T. T. Tang,B. LuAcute and gradual increases in BDNF concentration elicit very different signaling events and cellular responses in hippocampal neurons.Nature Neuroscience13, 302-309, 2010.Significant paper, demonstrated that a single extracellular factor could induce distinct signaling and functions based on how it is delivered.
9. K. Sakata, N. H. Woo, K. Martinowich, J. S. Greene, R. Schlosser, L. Shen,B. LuCritical role f promoter-IV-driven BDNF transcription in GABAergic transmission and synaptic plasticity in the prefrontal cortex,Pro. Natl. Acad. Sci.106, 5942–5947, 2009.Significant paper, discovered a role of activity-dependent BDNF expression in synaptic modulation distinct from basal BDNF expression.
10. N. H. Woo, C. J. Siao P. T. Pang, H. K. Teng, T. A.Milner, B. L. Hempstead,B. LuProBDNF/p75NTR signaling is necessary for hippocampal long-term depression.Nature Neuroscience8, 1069-1077, 2005.Significant paper, discovered the role of ProBDNF p75NTR signaling in synaptic plasticity, formed the basis for “Yin and Yang Hypothesis of Neurotrophin”.
11. P. T. Pang, H. K. Teng, N. Woo, E. Zaitsev, K. Sakata, S. Zhen, K. K. Teng, W.-H. Yung, B. L. Hempstead,B. LuCleavage of ProBDNF by the tPA/plasmin is essential for long-term hippocampal plasticity,Science306, 487-491, 2004.Significant paper, discovered the extracellular protease cleavage of proBDNF in the brain, and the role proBDNF to mature BDNF conversion in long-term synaptic plasticity.
12. M. F. Egan, M. Kojima, J. H. Callicott, T. E. Goldberg, B. S. Kolachana, E. Zaistev, A. Bertolino, B. Gold, D. Goldman, M. Dean,B. Lu, (co-corresponding author) and D. R. Weinberger A single nucleotide polymorphism in BDNF gene affects regulated secretion of BDNF and human memory and hippocampal function,Cell112, 257-269, 2003.Seminal paper, provided the first link between a human genetic polymorphism and cellular and cognitive function. Selected by Science as No. 2 in “10 Breakthrough of the Year”.
13. A. Figurov, L. Pozzo-Miller, T. Wang, P. Olafsson,B. LuRegulation of synaptic responses to high-frequency stimulation and LTP by neurotrophins in the hippocampus,Nature381, 706-709, 1996.Seminal paper, viewed as pioneering study of neurotrophin regulation of synaptic plasticity.
14. T. Wang, K. Xie, andB. LuNeurotrophins promote maturation of developing neuromuscular synapses. J. Neurosci. 15, 4796-4805, 1995.Significant paper, first report of long-term regulation of synapses by neurotrophins.
15. H. G. Kim, T. Wang, P. Olafsson, andB. LuNeurotrophin-3 potentiates neuronal excitability and inhibits g-aminobutyratergic synaptic transmission in cortical neurons,Proc. Natl. Acad. Sci. USA91, 12341-12345, 1994.Significant paper, first demonstration of acute effects of a neurotrophin on CNS neurons and synapses.
首要的综述(共35篇已经颁发)
1.B. Lu,G. Nagappan, X. Guan, and P. Wren (2013) BDNF-based synaptic repair as a disease-modifying strategy for neurodegenerative diseases.Nature Review Neuroscience.14, 401-416.
2. K. Martinowich, H. Manji,B. LuNew insights into BDNF function in depression and anxiety,Nature Neuroscience10, 1089-1093, 2007.Significant paper, provide new perspectives to mechanisms underlying psychiatric disorders based on advances in BDNF cell biology.
3.B. Lu, N. H. Woo, and P. T. Pang Yin and Yang of neurotrophin regulation,Nature Review Neuroscience8, 603-614, 2005.Significant paper, proposed “Yin-Yang hypothesis”: pro to mature neurotrophins elicit opposing roles through distinct receptors, and therefore proteolytic cleavage of proneurotrophis may control the direction of neurotrophin actions.
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